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BAK treatment increased the expression and activity of SIRT1 and nuclear accumulation of Nrf2 in diabetic hearts. (a) Representative blots. (b) SIRT1 expression. (c) Relative SIRT1 activity. (d) Nrf2 nuclear translocation. Data are presented as the mean ± SEM (n = 6 in each group). ∗/∗∗P < 0.05/0.01 vs. the control group, #/##P < 0.05/0.01 vs. the DM group, and &/&&P < 0.05/0.01 vs. the DM+BAK group.
