Figure 6.

Silencing cutaneous C fibers causes distinct age-related decreases in S1 γ and β oscillatory energy. Differences in the energy evoked by stimulation after QX-314 treatment versus before treatment in P14, P21, and P30 S1 (n = 6 animals per age). The paired mean difference at 500–1000 and 1000–1500 ms poststimulus are shown for each frequency band [δ (2–4 Hz), θ (5–7 Hz), α (8–12 Hz), β (15–29 Hz), and γ (30–90 Hz)]. Mean differences are depicted as dots; 95% confidence intervals are indicated by the ends of the vertical error bars. A negative value indicates a decreased energy following QX treatment compared before treatment and can be attributed to silencing of C fibers. Significant decreases in γ and β energy occur at P30. A decrease in β energy at P21 at 0–500 ms is not shown. See text for effect sizes, confidence intervals and permutation p values. Each paired mean difference is plotted as a bootstrap sampling distribution, using 5000 bootstrap samples, and the confidence intervals were bias corrected and accelerated (Ho et al., 2019).