Table 3.
AUC, sensitivity, specificity, PPV, NPV, +LR, and -LR of individual and combined markers for endometriosis.
| Marker | ROC-AUC | Sensitivity | Specificity | Positive predictive value | Negative predictive value | Positive likelihood ratio | Negative likelihood ratio |
|---|---|---|---|---|---|---|---|
| (95% CI) | |||||||
| Enolase-Cr | 0.443 (0.317-0.569) | 97.8 (88.7-99.9) | 13.5 (4.5-28.8) | 58.9 (55.94-62.27) | 83.3 (36.91-99.26) | 1.13 (0.8-52.0) | 0.16 (0.1-1.0) |
| CA125 | 0.220 (0.117-0.322) | 69.5 (54.2-82.3) | 86.5 (71.2-95.5) | 86.4 (73.37-93.6) | 69.5 (59.14-78.23) | 5.11 (1.8-5.5) | 0.35 (0.08-0.4) |
| CA19-9 | 0.359 (0.241-0.476) | 27.6 (15.6-42.6) | 100 (90.5-100.0) | 100 (90.1-100.0) | 52.1 (47.74-56.52) | — | 0.72 (0.2-1.6) |
| Enolase/Cr + CA125 + CA19 − 9 | 0.675 (0.573-0.710) | 65 (56.5-72.9) | 66.6 (57.1-75.3) | 71 (64.69-76.57) | 60.1 (53.82-66.28) | 1.94 (1.5-5.5) | 0.52 (0.4-0.7) |
The cut-off values for urinary enolase 1, enolase-Cr, CA125, and CA19-9 were 1181 ng/mL, 0.96 ng/mg Cr, 35 IU/mL, and 37 IU/mL, respectively. Abbreviations: ROC-AUC: areas under the receiver operating characteristic curves.