Table 1.
Main clinical features and serum Fetuin-B concentrations in PCOS and healthy women.
| Variable | PCOS (n = 257) | Controls (n = 141) | p value |
|---|---|---|---|
| Age (years) | 26.5 ± 3.8 | 26.3 ± 2.1 | NS |
| BMI (kg/m2) | 25.8 ± 4.6 | 20.2 ± 2.3 | <0.01 |
| FAT (%) | 36.7 ± 7.6 | 26.5 ± 5.4 | <0.01 |
| WHR | 0.87 ± 0.07 | 0.79 ± 0.06 | <0.01 |
| SBP (mmHg) | 116.4 ± 12.3 | 108.1 ± 8.5 | <0.01 |
| DBP (mmHg) | 74.6 ± 9.8 | 71.7 ± 9.0 | <0.01 |
| TC (mmol/L) | 4.47 ± 1.08 | 3.88 ± 0.88 | <0.01 |
| TG (mmol/L) | 1.81 ± 1.28 | 0.99 ± 0.66 | <0.01 |
| HDL-C (mmol/L) | 1.26 ± 0.99 | 1.29 ± 0.38 | NS |
| LDL-C (mmol/L) | 2.66 ± 0.78 | 2.20 ± 0.76 | <0.01 |
| FFAs (μmol/L) | 0.55 ± 0.21 | 0.55 ± 0.27 | NS |
| FBG (mmol/L) | 5.39 ± 0.76 | 4.53 ± 0.46 | <0.01 |
| 2 h-BG (mmol/L) | 7.82 (6.33-9.25) | 5.43 (4.71-6.32) | <0.01 |
| FIns (mU/L) | 18.42 (11.34-27.34) | 7.12 (5.96-8.72) | <0.01 |
| 2 h-Ins (mU/L) | 150.8 (99.1-249.6) | 41.9 (24.3-68.7) | <0.01 |
| M value (mg/kg/min) | 4.77 ± 2.13 | 10.18 ± 2.55 | <0.01 |
| § M value | 5.21 ± 0.13 | 9.14 ± 0.21 | <0.01 |
| HOMA-IR | 4.38 (2.64-6.95) | 1.41 (1.15-1.81) | <0.01 |
| §HOMA-IR | 5.67 ± 0.60 | 2.90 ± 0.89 | <0.05 |
| AUCi (mU × h/L) | 274.6 (194.6-397.5) | 111.1 (73.0-146.6) | <0.01 |
| AUCg (mmol × h/L) | 17.12 (14.82-18.90) | 11.98 (10.92-13.89) | <0.01 |
| Fetuin-B (mg/L) | 8.40 ± 5.02 | 6.22 ± 4.84 | <0.01 |
| §Fetuin-B | 7.65 ± 0.32 | 6.72 ± 0.59 | <0.05 |
| DHEA-S (μg/dL) | 278.2 ± 134.5 | 228.5 ± 108.4 | <0.01 |
| LH (IU/L) | 8.20 ± 5.00 | 4.59 ± 2.51 | NS |
| FSH (IU/L) | 6.36 ± 1.91 | 7.96 ± 1.93 | <0.01 |
| Estradiol (pg/mL) | 44.2 (33.7-57.8) | 44.4 (29.0-63.9) | NS |
| Prolactin (μg/L) | 14.46 ± 8.61 | 16.02 ± 8.08 | NS |
| Prog (nmol/L) | 1.67 (1.04-2.58) | 2.18 (1.41-3.12) | NS |
| SHBG (nmol/L) | 35.2 (24.9-49.5) | 61.3 (77.6-45.3) | <0.01 |
| TEST (nmol/L) | 2.08 ± 0.82 | 1.67 ± 0.77 | <0.01 |
| FAI | 6.99 ± 5.31 | 3.29 ± 2.77 | <0.01 |
BMI: body mass index; FAT (%): the percentage of body fat; WHR: waist-to-hip ratio; SBP: systolic blood pressure; DBP: diastolic blood pressure; TC: total cholesterol; TG: triglyceride; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; FFAs: free fatty acids; FBG: fasting blood glucose; 2 h-BG: 2 h blood glucose after glucose overload; FIns: fasting insulin; 2 h-Ins: 2 h insulin after glucose overload; HOMA-IR: HOMA-insulin resistance index; AUCi: the area under the curve for insulin; AUCg: the area under the curve for glucose; free androgen index (FAI) = TEST (nmol/L)/SHBG (nmol/L) × 100. LH: luteinizing hormone; FSH: follicle-stimulating hormone; DHEA-S: dehydroepiandrosterone-sulfate; SHBG: sex hormone-binding globulin; TEST: testosterone; Prog: progesterone. Values were given as means ± SD or median (interquartile Range). Values were given as means ± SD or median (interquartile Range). §Mean ± SE by a general linear model with adjustment of age and BMI.