Table 3.

Cox Regression Model Biomarker Beta Coefficients, Clinical Molecular Risk Score, and Clinical Molecular Signature Classification

Biomarker	HR	Beta Coefficient	95% CI		P
CA-125	12.2	2.502	0.89	4.11	.002
MMP7	4.63	1.532	0.38	2.68	.009
YKL-40	6.59	1.886	0.82	2.96	.001
OPN	4.98	1.605	0.25	2.96	.02
Age (1-unit increase)	0.92	−0.080	−0.15	−0.01	.03
FVC % predicted (1-unit increase)	0.97	−0.035	−0.07	0.00	.06
CMS risk score (CMS-RS) = 11−(2.502 × CA125 “high”) + (1.532 × MMP7 “high”) + (1.886 × YKL-40 “high”) + (1.605 × OPN “high”) − (0.08 × age) − (0.0.035 × FVC [% predicted]).
CMS-RS	Clinical Molecular Signature Classification
0-3.99	Low risk
4.0-9.0	High risk

OPN = osteopontin. See Table 1 and 2 legends for expansions of other abbreviations.