Table 2.
Adjusted Hazard Ratio (95% Confidence Limits) for the Likelihood of Coronary Heart Disease and Cardiovascular Events by Study Groups
| Hazard ratio (95% confidence interval) per standard deviation | |||
|---|---|---|---|
| Variable | MetS (without DM) (N= 1596) | DM (N= 838) | Neither DM nor MetS (N=3983) |
| CHD Events | 139 | 105 | 218 |
| ‡ Model 1: HDL Discordance | 0.84 (0.68–1.04) | 0.88 (0.72–1.08) | 0.94 (0.80–1.10) |
| § Model 2: LDL Discordance | 1.21 (1.01–1.47)* | 0.88 (0.71–1.10) | 0.87 (0.74–1.02) |
| || Model 3: | |||
| HDL-C | 1.12 (0.73–1.73) | 1.00 (0.70–1.43) | 1.14 (0.90–1.45) |
| HDL-P | 0.86 (0.63–1.17) | 0.71 (0.52–0.96)* | 0.82 (0.66–1.03) |
| LDL-C | 0.80 (0.59–1.08) | 1.47 (1.07–2.03)* | 1.27 (1.01–1.59)* |
| LDL-P | 1.34 (1.01–1.78)* | 0.82 (0.58–1.17) | 0.93 (0.71–1.22) |
| CVD Events | 200 | 152 | 307 |
| ‡ Model 1: HDL Discordance | 0.95 (0.80–1.13) | 0.90 (0.77–1.06) | 0.88 (0.77–1.01) |
| § Model 2: LDL Discordance | 1.26 (1.07–1.47) † | 0.88 (0.74–1.06) | 0.91 (0.79–1.04) |
| || Model 3: | |||
| HDL-C | 1.05 (0.74–1.48) | 0.98 (0.73–1.32) | 1.12 (0.92–1.37) |
| HDL-P | 0.97 (0.76–1.25) | 0.75 (0.58–0.97)* | 0.80 (0.66–0.96)* |
| LDL-C | 0.77 (0.60–1.00) | 1.41 (1.08–1.84)* | 1.17 (0.96–1.42) |
| LDL-P | 1.39 (1.09–1.75) † | 0.76 (0.57–1.02) | 0.99 (0.79–1.24) |
*
p < 0.05,
†
p<0.01
All models were adjustments for age, sex, race/ethnicity, family history, systolic blood pressure, use of blood pressure medication, smoking, body mass index, statin use.
‡
Model 1 additionally adjusted for LDL-C and LDL-P.
§
Model 2 additionally adjusted for HDL-C and HDL-P
||
Model 3 include simultaneous adjustment with all four lipid variables