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. 2020 Sep 10;7(10):1870–1882. doi: 10.1002/acn3.51172

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© 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Longitudinal observational data on gross motor abilities in LAMA2‐RD patients. Each horizontal line indicates single patients. Symbol on lines indicates different assessments in each patient. Panel A: patients with severe phenotype/complete deficiency (CD). Panel B: patients with milder phenotype/partial deficiency (PD). Cross: not able to sit with support; triangle: sitting with support, circle: sitting without support; diamond: walking with support; asterisk: walking alone; arrowhead: running. The continuous vertical line at 9 months and dashed line at 18 months indicates WHO thresholds for attaining independent sitting and walking alone in 99% of children.