Figure 2.

Voxel‐Based Morphometry analyses showing significantly decreased regions in patients compared with HC at both baseline (blue) and follow‐up (red). The depicted regions are those that survived multiple comparisons adjusted for age and brain size. Panel 2A) shows the masks where pediatric onset patients obtained lower gray matter values than their corresponding HC‐pediatric group. Panel 2B) shows the masks where adult/late onset patients had lower gray matter values than their corresponding HC‐adult/late group. The mask at baseline is represented with transparency in order to visualize the areas of overlap between baseline and follow‐up (dark blue and dark brown) and the non‐overlapping areas (light blue and light brown).