Table 3.
Cross‐sectional (inter‐group) and longitudinal (intra‐group and inter‐group) comparisons for GM and WM volume.
| N | Mean | SD | DM1 versus HC | Mean | SD | DM1 versus HC | Intra‐group Follow‐up ‐ Baseline | Intergroup comparison of percentage of volume loss | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Z | P | Mean | F | P | gHedges | ||||||||
| Baseline | Follow‐up | ||||||||||||
| Pediatric DM1 versus HC‐pediatric | |||||||||||||
| GM volume | t = 4.208 | t = 5.071 | |||||||||||
| DM1 | 9 | 728492.55 | (59435.88) | p = 0.000 | 703854.60 | (53407.41) | P = 0.000 | −1.836 | 0.066 | −3.86 ¶ | 3.497 | 0.078 | 0.94 |
| HC | 12 | 829069.52 | (50050.01) | d = 1.86 | 819800.71 | (50693.01) | d = 2.24 | −1.569 | 0.117 | −0.63 ¶ | |||
| WM volume | |||||||||||||
| DM1 | 9 | 656340.98 | (45830.39) | t = 4.334 | 658010.04 | (28468.26) | t = 4.643 | −0.296 | 0.767 | −0.25 ¶ | 0.097 | 0.759 | 0.16 |
| HC | 12 | 721993.51 | (22597.64) | p = 0.000 | 712342.09 | (25040.87) | p = 0.000 | −1.412 | 0.158 | −0.77 ¶ | |||
| d = 1.91 | d = 2.05 | ||||||||||||
| Adult/late DM1 versus HC‐adult/late | |||||||||||||
| GM volume | t = 2.172 | t = 2.324 | |||||||||||
| DM1 | 12 | 756500.85 | (42058.37) | p = .040 | 737651.22 | (52119.48) | p = 0.029 | −1.961 | 0.050 | −2.71 $ | 1.721 | 0.203 | 0.57 |
| HC | 14 | 787456.64 | (30440.24) | d = .85 | 779936.16 | (40616.75) | d = 0.91 | −1.475 | 0.140 | −0.85 $ | |||
| WM volume | |||||||||||||
| DM1 | 12 | 703532.11 | (40638.08) | t = 1.582 | 685715.24 | (36237.65) | t = 1.256 | −3.059 | 0.002 | −2.63 $ | 0.106 | 0.748 | 0.14 |
| HC | 14 | 727201.95 | (35684.99) | p = 0.127 | 704947.47 | (41037.58) | p = 0.221 | −2.856 | 0.004 | −2.97 $ | |||
| d = 0.62 | d = 0.49 | ||||||||||||
DM1: Myotonic Dystrophy Type 1; HC: Healthy controls; SD: Standard Deviation. Longitudinal inter‐group comparisons of percentage of volume loss are calculated using time to follow‐up as a covariate.
¶
Covariate value: 9.1624.
$
Covariate value: 9.0973.