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. 2020 Oct 8;10(10):e037879. doi: 10.1136/bmjopen-2020-037879

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Study process diagram. AEs, adverse events; HADS, Hospital Anxiety and Depression Scale; NRS, Numerical Rating Scale; PGIC, patient global impression of change; TcPO₂, transcutaneous oxygen pressure; TOI, Tissue Haemoglobin Index.