Table 1.
Baseline Characteristics of the Participants.a
| Characteristics | RC 2-3: Claudicantsb (n=214) | RC 4-5: CLTI (n=233) | RC 6: CLTI (n=56) | p |
|---|---|---|---|---|
| Age, y | 70.4±9.6 | 71.3±10.9 | 67.9±14.2 | 0.106 |
| Men | 149/214 (69.6) | 138/233 (59.2) | 40/56 (71.4) | 0.154 |
| Race | ||||
| American Indian or Alaska Native | 1/214 (0.5) | 1/233 (0.4) | 0/56 | >0.99 |
| Asian | 1/214 (0.5) | 1/233 (0.4) | 1/56 (1.8) | 0.467 |
| Black or African American | 26/214 (12.1) | 26/233 (11.2) | 13/56 (23.2) | 0.068 |
| Native Hawaiian or Other Pacific Islander | 0/214 | 1/233 (0.4) | 0/56 | >0.99 |
| White | 181/214 (84.6) | 198/233 (85.0) | 42/56 (75.0) | 0.178 |
| Other | 5/214 (2.3) | 6/233 (2.6) | 0/56 | 0.753 |
| BMI, kg/m2 | 28.8±5.5 | 29.1±6.7 | 29.3±7.1 | 0.785 |
| eGFR, mg/dL/1.73 m2 | 69.0±28.6 | 58.3±26.4 | 57.2±34.4 | <0.001 |
| Smoking history | 0.128 | |||
| Current | 44/214 (20.6) | 41/233 (17.6) | 10/56 (17.9) | 0.731 |
| Former | 111/214 (51.9) | 100/233 (42.9) | 26/56 (46.4) | 0.166 |
| Diabetes | 109/214 (50.9) | 157/233 (67.4) | 44/56 (78.6) | <0.001 |
| Hyperlipidemia | 195/214 (91.1) | 207/233 (88.8) | 38/56 (67.9) | <0.001 |
| Hypertension | 201/214 (93.9) | 218/233 (93.6) | 52/56 (92.9) | 0.931 |
| Renal disease | 55/214 (25.7) | 99/233 (42.5) | 23/56 (41.1) | <0.001 |
| Hemodialysis | 9/55 (16.4) | 20/99 (20.2) | 10/23 (43.5) | 0.033 |
| Coronary artery disease | 132/214 (61.7) | 157/233 (67.4) | 28/56 (50.0) | 0.047 |
| Myocardial infarction | 46/214 (21.5) | 66/233 (28.3) | 9/56 (16.1) | 0.085 |
| Stroke/TIA | 39/214 (18.2) | 36/233 (15.5) | 4/56 (7.1) | 0.112 |
| Runoff vesselsc | 179 | 215 | 47 | 0.141 |
| Pretreatment | ||||
| 3 | 33/179 (18.4) | 32/215 (14.9) | 8/47 (17.0) | 0.654 |
| 2 | 69/179 (38.5) | 82/215 (38.1) | 18/47 (38.3) | >0.99 |
| 1 | 67/179 (37.4) | 83/215 (38.6) | 12/47 (25.5) | 0.232 |
| 0 | 10/179 (5.6) | 18/215 (8.4) | 9/47 (19.1) | 0.018 |
| Posttreatment | 0.96 | |||
| 3 | 32/147 (21.8) | 38/181 (21.0) | 7/36 (19.4) | 0.982 |
| 2 | 61/147 (41.5) | 80/181 (44.2) | 14/36 (38.9) | 0.785 |
| 1 | 51/147 (34.7) | 61/181 (33.7) | 15/36 (41.7) | 0.653 |
| 0 | 3/147 (2.0) | 2/181 (1.1) | 0/36 | 0.795 |
| Previous EVT of target limb | 58/214 (27.1) | 71/233 (30.5) | 14/56 (25.0) | 0.172 |
| Previous bypass surgery of target limb | 9/214 (4.2) | 9/233 (3.9) | 4/56 (7.1) | 0.397 |
| Prior stent placed in target limb | 31/214 (14.5) | 28/233 (12.0) | 7/56 (12.5) | 0.889 |
Abbreviations: BMI, body mass index; eGFR, estimated glomerular filtration rate; EVT, endovascular therapy; ICU, intensive care unit; RC, Rutherford category; TIA, transient ischemic attack.
a
Continuous data are presented as the mean ± standard deviation (sample size if different from the group number); categorical data are given as the number/sample (percentage). Sample sizes may differ from the group number owing to missing data.
b
Two patients (with a total of 3 wounds) were classified as RC 2-3 by the treating physician and therefore were analyzed with that group.
c
As determined by the core laboratory.