Table 2.
Univariate and multivariate analyses of OS in ICGC-LIRI-JP (n=203) cohort by Cox regression analysis
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | CI (95%) | P value | HR | CI (95%) | P value | |
| Age (years) | 0.922 | 0.325-2.616 | 0.878 | |||
| Gender | 0.536 | 0.265-1.083 | 0.082 | |||
| Virus (HBV or/and HCV) | 1.654 | 0.506-5.408 | 0.406 | |||
| TNM stage | 2.830 | 1.446-5.540 | 0.002* | |||
| Portal vein invasion | 3.135 | 1.595-6.160 | 0.001* | |||
| Vein invasion | 2.394 | 1.172-4.891 | 0.017* | |||
| Fibrosis | 1.158 | 0.276-4.853 | 0.841 | |||
| Alcohol | 0.476 | 0.242-0.936 | 0.031* | 0.311 | 0.150-0.646 | 0.002* |
| Smoking | 0.758 | 0.391-1.471 | 0.413 | |||
| UPK1A | 2.121 | 1.092-4.119 | 0.026* | 2.479 | 1.243-4.943 | 0.010* |
Abbreviations: HBV, hepatitis B virus; HCV, hepatitis C virus; CI, confidence interval; HR, hazard radio; *The values had statistically significant differences.