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. 2020 Sep 16;16(15):2938–2950. doi: 10.7150/ijbs.47051

Figure 4.

Figure 4

Lnc-MCEI functioned as a competing endogenous RNA (ceRNA) via sponging miR-6759-5p. A. The putative binding site of lnc-MCEI and miR-6759-5p was analysed by LncBase v2.0 database. B. The significantly down-regulated miR-6759-5p were observed in ESCC tissues compared to the normal controls. N = 50. C. The significantly down-regulated miR-6759-5p were also observed in ESCC tissues compared to the matched normal tissues. N = 50. D. miR-6759-5p was down-regulated in ESCC cell lines compared to the human esophageal epithelial cell line (Het-1A). E. A significant negative correlation between the expression of lnc-MCEI and that of miR-6759-5p. F. Luciferase activity of wild-type or mutated lnc-MCEI in HEK-293T cells examined by the dual luciferase reporter assays. G. Relative lnc-MCEI levels in KYSE-30 cells treated with miR-6759-5p mimics or miR-6759-5p inhibitor. H. RNA immunoprecipitation (RIP) were performed to examine the interaction between lnc-MCEI and miR-6759-5p. *P < 0.05.