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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: J Mol Cell Cardiol. 2020 Apr 14;142:138–145. doi: 10.1016/j.yjmcc.2020.04.015

Figure 2. Mitophagy is mediated by either Drp1-dependent or -independent mechanisms.

Figure 2.

In Drp1-dependent mitophagy, mitochondrial fission mediated by Drp1 segregates damaged mitochondria, which are then degraded by LC3-dependent autophagy (a). Drp1 is also involved in alternative mitophagy, which occurs through a Ulk1/Rab9/Rip1-dependent mechanism. In this case, Drp1 is translocated to mitochondria through Rip1-mediated phosphorylation at Ser616 and forms a complex with Rab9 in an Ulk1-dependent manner (b). In Drp1-independent mitophagy, Parkin marks depolarized mitochondria, and separation and sequestration of damaged mitochondria into autophagosomes occur through a common mechanism in an LC3-dependent manner (c).