In Drp1-dependent mitophagy, mitochondrial fission mediated by Drp1 segregates damaged mitochondria, which are then degraded by LC3-dependent autophagy (a). Drp1 is also involved in alternative mitophagy, which occurs through a Ulk1/Rab9/Rip1-dependent mechanism. In this case, Drp1 is translocated to mitochondria through Rip1-mediated phosphorylation at Ser616 and forms a complex with Rab9 in an Ulk1-dependent manner (b). In Drp1-independent mitophagy, Parkin marks depolarized mitochondria, and separation and sequestration of damaged mitochondria into autophagosomes occur through a common mechanism in an LC3-dependent manner (c).