Figure 1.

Concentration-dependent inhibition of LTP at hippocampal CA3-CA1 synapses by ketamine. (A) Representative fEPSP traces (averages of four successive sweeps at the time indicated by a–c in panel B) for vehicle control (black) and 10 µM ketamine (green). (B) Time course normalised plots for these experiments. Each point plots the average of four successive sweeps. (C) Pooled data for control (n = 7), and ketamine applied at 1 µM (n = 4), 3 µM (n = 4) and 10 µM (n = 5). TBS was delivered at the time indicated by an arrow.