Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 28;4:2398212820957847. doi: 10.1177/2398212820957847

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PMC Copyright notice

Figure 2. — (2S,6S)-HNK and (2R,6R)-HNK inhibit the induction of LTP. (A) Representative traces of fEPSPs for (2S,6S)-HNK (upper) and (2R,6R)-HNK (lower), both at 10 µM. (B) Time-course plots of single experiments for a control (black), (2S,6S)-HNK (blue) and (2R,6R)-HNK (red) experiment. (C) Pooled data for control (n = 7), 10 µM (2S,6S)-HNK (n = 5) and 10 µM (2R,6R)-HNK (n = 4). (D) Summary histograms of the level of LTP, measured 20 min after delivery of TBS. *p < 0.05, **p < 0.01, ***p < 0.001 (one-way ANOVA with Bonferroni’s correction compared to vehicle control). (E) Concentration–response curves for inhibition of LTP by ketamine (13 slices), (2S,6S)-HNK (15 slices) and (2R,6R)-HNK (6 slices). A comparison of IC₅₀ values showed that (2S,6S)-HNK inhibited LTP with a greater potency than (2R,6R)-HNK (p < 0.05, extra sum-of-squares F test). (F) Baseline fEPSP slope measurements prior to delivery of TBS for the different experimental conditions.