Table 3.
Mixed-effects linear models of cognitive and physical functions by Aβ+NfL+ conditions
| Parameters | Aβ+NfL+ group × time (all participants)# | Aβ+NfL+ group × time (with APOE)# | ||||||
|---|---|---|---|---|---|---|---|---|
| Coefficient | p | Adjusted p∆ | 95%CI | Coefficient | p | Adjusted p∆ | 95%CI | |
| CCS | − 0.11 | 0.0004 | 0.002 | (− 0.17, − 0.05) | − 0.09 | 0.007 | 0.03 | (− 0.15, − 0.02) |
| MMSE | − 0.14 | 0.18 | 0.24 | (− 0.34, 0.06) | − 0.06 | 0.55 | 0.74 | (− 0.27, 0.14) |
| Gait speed (m/s) | − 0.03 | 0.02 | 0.04 | (− 0.05, − 0.005) | − 0.02 | 0.08 | 0.17 | (− 0.05, 0.003) |
| Chair-stand time (s) | 0.08 | 0.66 | 0.66 | (− 0.28, 0.44) | − 0.001 | 0.99 | 0.99 | (− 0.38, 0.38) |
Covariates: age, sex, body mass index, education level and MAPT group
#Participants without Aβ+NfL+ condition as the reference
∆p value adjusted by Benjamini–Hochberg procedure