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. Author manuscript; available in PMC: 2020 Oct 9.
Published in final edited form as: Neurobiol Dis. 2020 Jan 3;136:104725. doi: 10.1016/j.nbd.2019.104725

Fig. 7.

Fig. 7.

Adaptaquin partially restores the loss of TH immunoreactivity in the striatum of 6-OHDA-injected mice. Quantification (A) and representative images (B) of TH immunohistochemistry (brown) showing the optical density of the TH signal from dopaminergic fibers in the unlesioned (control) or 6-OHDA lesioned (experimental) side of the striatum of mice who received a sham surgery or a 6-OHDA lesion and either a control IP injection (6-OHDA) or a daily 30 mg/kg IP injection of AQ for 7 consecutive days (AQ + 6-OHDA). 6-OHDA induces a drastic reduction of TH immunostaining in experimental side of the striatum, relative to the control side and compared to sham mice (ANOVA with Tukey’s post-hoc test ****p < .0001). AQ post-treatment for 7 days significantly increases the proportion of TH immunoreactivity in the striatum (ANOVA with Tukey’s post-hoc test ***p < .001). Given the variability in the AQ + 6-OHDA group, striatum images of 3 individual mice are shown in B.