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. Author manuscript; available in PMC: 2020 Oct 9.
Published in final edited form as: Neurobiol Dis. 2020 Jan 3;136:104725. doi: 10.1016/j.nbd.2019.104725

Fig. 8.

Fig. 8.

Adaptaquin partially restores movement control in 6-OHDA-injected mice. (A–D) Behavioral analysis by quantification of the net contralateral rotations induced by a subcutaneous injections of apomorphine at 7 days (A), 14 days (B), 21 days (C) and 28 days after mice received a sham surgery or a 6-OHDA lesion and either a control IP injection (6-OHDA) or a daily 30 mg/kg IP injection of AQ for 7 consecutive days (AQ + 6-OHDA). n = 5 for sham, n = 13 for 6-OHDA alone and n = 13 for AQ + 6-OHDA group. 6-OHDA induces a drastic increase in the number of contralateral rotations at all time points measured compared to sham mice (ANOVA with Tukey’s post hoc test; *p < .05, ***p < .0005). AQ post-treatment for 7 days significantly decreases the number of contralateral rotations at 14 days, 21 days and 28 days (ANOVA with Tukey’s post hoc test; ***p < .0005, ****p < .0001). (E–G) Correlation analysis of the results of the AQ-treated group showing that the number of dopaminergic neurons in the substantia nigra is highly correlated to the density of TH immunoreactivity in the striatum (E, Pearson correlation coefficient r = 0.968, p < .0001), the density TH immunoreactivity in the striatum is highly correlated to the number of apomorphine-induced rotations (F, Pearson correlation coefficient r = −0.966, p < .0001) and the number of dopaminergic neurons in the substantia nigra is highly correlated to the number of apomorphine-induced rotations (G, Pearson correlation coefficient r = −0.971, p < .0001).