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SPP1 acts as a biomarker for diagnosis and progression of melanoma through meta-analysis. (A-B) Forest plot of SPP1 expression between nevi and PM (A), between nevi and MM (B) based on immunohistochemistry staining. (C-E) Forest plot of SPP1 expression between health persons and MM (C), between PM and MM patients (D), between patients who were disease free (DF) for at least five years and MM patients (E) based on enzyme linked immunosorbent assay. (F) Sensitivity analysis.
