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. 2020 Sep 15;10(25):11428–11443. doi: 10.7150/thno.47432

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Overexpression of SPP1 partially reversed the inhibition effects of BET inhibitors in melanoma. (A) The efficiency of SPP1 overexpression in A375 cells were evaluated by RT-PCR and western blotting. (B-D) The influence of SPP1 overexpression on proliferation of A375 cells treated with NHWD-870 (5nM) (B), JQ-1 (500nM) (C), and BMS-986158 (10nM) (D). (E-G) The influence of SPP1 overexpression on migration (E-F) and invasiveness (G) ability of A375 cells treated with NHWD-870 (5nM), JQ-1 (500nM), and BMS-986158 (10nM). All data were presented as mean ± SD of three independent experiments. *, P < 0.05; **, P < 0.01; ***, P < 0.001.