Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A model depicting that inhibition of BRD4 represses SPP1 expression by transcriptionally down-regulating NFKB2 in melanoma. BRD4 promotes NFKB2 expression via direct binding to the NFKB2 promoter. Inhibition of BRD4 by BET inhibitor decreases NFKB2 expression, then represses the expression of SPP1, resulting in impeding melanoma proliferation, migration, and invasion.
