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. 2020 Sep 19;10(25):11637–11655. doi: 10.7150/thno.48064

Figure 7.

Figure 7

PU.1 upregulation is concomitant with NOX4- p22phox complex synthesis. (A) PU.1, p22phox (CYBA), and NOX4 expression and quantification in mouse RPE cells after 2, 4, and 6 days of Aβ1-40 treatment. (B) Co-IP of NOX4 and p22phox (CYBA) at 4 days after the injection of Aβ1-40 or PBS. (C, D) Retinal sections were immuno-stained for NOX4 (C) and p22phox (D) at 4 days post-injection. The lower parts of the images are magnified portions of the RPE layer from the upper parts of the images (white boxes). Scale bar = 50 µm; all data are presented as the mean ± SEM; n = 3 for each group. NS = nonsignificant, ***P < 0.001, Student's t-test.