| MASP2 |
Activation of complement by its serum protease activity via mannose-binding lectin. Cleaves and activates C2 and C4, resulting in formation of C3 convertase |
N |
N |
N |
| FURIN |
Endoprotease with the ability to cleave at the RX(K/R)R consensus motif. Required for H7N1 and H5N1 influenza virus infection by hemagglutinin cleavage [32] |
S |
S |
S |
| TMPRSS2 |
Promotes SARS-CoV and SARS-CoV-2 infections via proteolytic cleavage of Angiotensin-converting enzyme 2 (ACE2) receptor promoting viral uptake, and cleavage of spike glycoproteins of coronavirus and its activation for host cell entry [33, 34] |
S |
S |
S |
| ACE2 |
Receptor for entry of SARS-CoV and SARS-CoV-2, NL63/HCoV-NL63 |
– |
S |
S |
| BZW2 |
May be involved in neuronal differentiation |
– |
nsp8ab |
M |
| TBK1 |
Serine/threonine kinase playing an important role in inflammatory responses against foreign substances |
– |
nsp5ab |
nsp13 |
| SMOC1 |
Important roles in eye and limb development. Probably regulates differentiation of osteoblast |
– |
ORF7a |
ORF8 |
| MARK3 |
It is a serine/threonine-protein kinase [35], which is involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4 and phosphorylate MAPT/TAU. It negatively regulates hippo signaling pathway |
– |
ORF9b,nsp13ab |
ORF9b |
| MARK2 |
It is a serine/threonine protein kinase [35], which is involved in cell polarity and microtubule dynamics regulation |
– |
nsp13ab |
ORF9b |
| TRIM25 |
Ubiquitin E3 ligase and ISG15 E3 ligase [36], which is implicated in innate immune response for viruses [37, 38]. Mediates signal transduction leading to the production of interferons against viral infection [37, 39] |
N |
N |
– |
| RCHY1 |
E3-dependent ubiquitination and proteasomal degradation of target proteins. Involved in the cell cycle progression regulation and enhance androgen receptor (AR) transcription factor activity |
nsp3ab |
nsp3ab |
– |
