TABLE 5.
Outcomes of Infants With and Without Exposure to iNO in Infants With Early HRF
| Characteristics | Exposed to iNO, n = 338 | Not Exposed to iNO, n = 1394 | P |
|---|---|---|---|
| BPD, traditional, n (%) | 157 of 172 (91.3) | 584 of 805 (72.5) | <.0001 |
| BPD, physiologic definition, n (%) | 157 of 171 (91.8) | 556 of 800 (69.5) | <.0001 |
| PDA, treatment and surgery, n (%) | 202 of 337 (59.9) | 697 of 1391 (50.1) | .0012 |
| Postnatal steroid use for BPD, n (%) | 107 of 324 (33.0) | 240 of 1312 (18.3) | <.0001 |
| NEC stage II/III, n (%) | 27 of 338 (8.0) | 145 of 1393 (10.4) | .182 |
| Early-onset sepsis, n (%) | 18 of 338 (5.3) | 41 of 1393 (2.9) | .0304 |
| Late-onset of sepsis, n (%) | 124 of 312 (39.7) | 386 of 1192 (32.4) | .0145 |
| ROP stage ≥III, n (%) | 63 of 178 (35.4) | 235 of 811 (29.0) | .0911 |
| Grade 3 or 4 IVH and PVL, n (%) | 112 of 324 (34.6) | 518 of 1290 (40.2) | .0653 |
| Length of stay survivors, d, mean ± SD | 150.8 ± 70.2 | 129.3 ± 51.8 | <.0001 |
| Mortality in the NICU, n (%) | 183 of 338 (54.1) | 617 of 1389 (44.4) | .0013 |
| 18–26 mo, characteristics among NICU survivors | n = 137 | n = 677 | |
| Intact survival, no death or severe NDI, n (%) | 73 of 137 (53.3) | 387 of 675 (57.3) | .3833 |
| Death after NICU discharge, n (%) | 7 of 137 (5.1) | 23 of 677 (3.4) | .332 |
| Moderate-severe NDI, n (%) | 57 of 130 (43.8) | 265 of 652 (40.6) | .4982 |
| Cerebral palsy, n (%) | 32 of 129 (24.8) | 141 of 654 (21.6) | .4166 |
| Moderate to severe cerebral palsy, n (%) | 16 of 129 (12.4) | 84 of 653 (12.9) | .8862 |
| Bayley-III cognitive, mean ± SD | 84.1 ± 17.4 | 84.4 ± 16.6 | .8339 |
| Hearing impairment, n (%) | 7 of 130 (5.4) | 28 of 653 (4.3) | .5805 |
| Loss of vision, n (%) | 3 of 129 (2.3) | 19 of 652 (2.9) | .712 |