TABLE 3.
Risk of Dichotomized Socioemotional Outcomes at End of 180-Day Trial, Omega Tots Trial, 2012–2017
| DHA + AA/Placebo, No. at End of Trial | Caregiver Endorsed at End of 180-d Trial, n (%) | RR (95% CI) | RD (95% CI) | Interaction Term P, Child Sex | ||
|---|---|---|---|---|---|---|
| DHA + AA | Placebo | |||||
| Full sample | ||||||
| BITSEA competence, delayed | 161/152 | 22 (14) | 25 (16) | 0.87 (0.50 to 1.50) | −0.02 (−0.10 to 0.06) | .15 |
| BITSEA competence, ASD risk cutoff | 161/152 | 32 (20) | 35 (23) | 0.91 (0.59 to 1.42) | −0.02 (−0.11 to 0.07) | .05 |
| BITSEA problem, delayed | 161/153 | 35 (22) | 35 (23) | 0.97 (0.64 to 1.48) | −0.01 (−0.10 to 0.09) | .45 |
| BITSEA problem, ASD risk cutoff | 161/153 | 42 (26) | 39 (25) | 1.07 (0.73 to 1.55) | 0.02 (−0.08 to 0.12) | .56 |
| BITSEA ASD, ASD risk cutoff | 161/152 | 39 (24) | 45 (30) | 0.88 (0.60 to 1.28) | −0.03 (−0.14 to 0.07) | .003 |
| PDDST-II, fail | 160/153 | 33 (21) | 49 (32) | 0.66 (0.45 to 0.97) | −0.11 (−0.21 to −0.01) | .29 |
| Female sex | ||||||
| BITSEA competence, delayed | 69/81 | 6 (9) | 15 (19) | 0.52 (0.21 to 1.28) | −0.08 (0.05 to −0.18) | — |
| BITSEA competence, ASD risk cutoff | 69/81 | 8 (12) | 21 (26) | 0.57 (0.30 to 1.07) | −0.09 (−0.20 to 0.01) | — |
| BITSEA problem, delayed | 69/81 | 13 (19) | 19 (23) | 0.86 (0.47 to 1.57) | −0.03 (−0.16 to 0.10) | — |
| BITSEA problem, ASD risk cutoff | 69/81 | 15 (22) | 19 (23) | 0.99 (0.56 to 1.74) | 0.00 (−0.14 to 0.13) | — |
| BITSEA ASD, ASD risk cutoff | 69/81 | 9 (13) | 28 (35) | 0.43 (0.22 to 0.85) | −0.18 (−0.31 to −0.05) | — |
| PDDST-II, fail | 69/81 | 17 (25) | 25 (31) | 0.81 (0.48 to 1.36) | −0.06 (−0.20 to 0.08) | — |
| Male sex | ||||||
| BITSEA competence, delayed | 92/71 | 16 (17) | 10 (14) | 1.19 (0.55 to 2.56) | 0.03 (−0.09 to 0.14) | — |
| BITSEA competence, ASD risk cutoff | 92/71 | 24 (26) | 14 (20) | 1.31 (0.72 to 2.38) | 0.06 (−0.07 to 0.19) | — |
| BITSEA problem, delayed | 92/72 | 22 (24) | 16 (22) | 1.08 (0.61 to 1.91) | 0.02 (−0.11 to 0.15) | — |
| BITSEA problem, ASD risk cutoff | 92/72 | 27 (29) | 20 (28) | 1.11 (0.66 to 1.85) | 0.03 (−0.12 to 0.18) | — |
| BITSEA ASD, ASD risk cutoff | 92/71 | 30 (33) | 17 (24) | 1.37 (0.81 to 2.31) | 0.09 (−0.05 to 0.23) | — |
| PDDST-II, fail | 91/72 | 16 (18) | 24 (33) | 0.54 (0.31 to 0.95) | −0.15 (−0.30 to −0.01) | — |
—, not applicable.