Table 1.
Summary of 25 studies included in systematic review.
| Reference | Journal | Region | Setting | Sample size | Severe, n (%) | Age median (IQR) or mean (SD) in y | Male, n (%) | Current smoking, n (%) | HTN, n (%) | DM, n (%) | CVD, n (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Bhatraju PK | NEJM | USA | 9 Seattle-area hospitals | 24 | 18 (75) | 64 (18) | 15 (63) | 5 (22)* | – | 14 (58) | 2 (8) |
| Cao J | Intensive Care Med | China | Zhongnan Hospital | 102 | 18 (18) | 54 (37–67) | 53 (52) | – | 28 (28) | 11 (11) | 5 (5) |
| Chen J | J Infect | China | Shanghai Public Health Clinical Center | 249 | 22 (9) | 51 (36–64) | 126 (51) | – | – | – | 55 (22) |
| Chen T | BMJ | China | Tongji Hospital | 274 | 196 (72) | 62 (44–70) | 170 (62) | 11 (4) | 93 (34) | 47 (17) | 22 (8) |
| Cheng Y | Kidney International | China | Tongji Hospital | 701 | 113 (16) | 63 (50–71) | 367 (52) | – | 233 (33) | 100 (14) | |
| China CDC | CCDC | China | China National Data | 44,672 | 8,255 (19) | – | 22,981 (51) | – | 2,683 (13) | 1,102 (5) | 873 (4) |
| Deng Y | Chin Med J | China | Tongji Hospital and Central Hospital of Wuhan | 225 | 109 (48) | – | 124 (55) | – | 58 (26) | 26 (12) | 17 (8) |
| Guan W | NEJM | China | 552 hospitals in 30 provinces | 1099 | 67 (6) | 47 (35–58) | 637 (58) | 137 (13) | 165 (15) | 81 (7) | 27 (3) |
| Guo T | JAMA Cardiol | China | Seventh Hospital of Wuhan | 187 | 43 (23) | 59 (15) | 91 (49) | 18 (10) | 61 (33) | 28 (15) | 21 (11) |
| Huang C | Lancet | China | Jinyintan Hospital | 41 | 13 (32) | 49 (41–58) | 30 (73) | 3 (7) | – | – | 6 (15) |
| Lian J | Clin Infect Dis | China | Hospitals in Zhejiang province | 788 | 77 (10) | 46 (15) | 407 (52) | 54 (7) | 126 (16) | 57 (7) | 11 (1) |
| Liang W | Lancet Oncology | China | 575 hospitals across China | 1,590 | 131 (8) | 49 ± 16 | 909 (57) | 111 (7) | – | – | – |
| Onder G | JAMA | Italy | Italy National Data | 22,512 | 1,625 (7) | – | – | – | – | – | – |
| Ruan Q | Intensive Care Med | China | Jinyintan Hospital and Tongji Hospital | 150 | 67 (45) | – | 102 (68) | – | 52 (35) | – | 13 (9) |
| Shi S | JAMA Cardiol | China | Zhejiang Province | 416 | 97 (23) | 64 (21–95) | 205 (49) | – | 127 (31) | 60 (14) | 44 (11) |
| Tang N | J Thromb Haemost | China | Tongji Hospital | 183 | 21 (12) | 54 ± 16 | 98 (54) | – | – | – | – |
| US CDC | MMWR | US | US National Data | 2,449 | 121 (5) | – | – | – | – | – | – |
| US CDC_2 | MMWR | USA | US National Data | 6,637 | 457 (6) | – | – | 86 (1) | 106 (2) | 723 (11) | 597 (9) |
| Wang D | JAMA | China | Zhongnan Hospital | 138 | 36 (26) | 56 (42–68) | 75 (54) | – | 43 (31) | 14 (10) | 20 (15) |
| Wang L | J Infect | China | Renmin Hospital of Wuhan University | 339 | 80 (24) | 69 (65–76) | 166 (49) | – | 138 (41) | 54 (16) | 53 (16) |
| Wu C | JAMA Intern Med | China | Jinyintan Hospital, Wuhan | 201 | 84 (42) | 51 (43–60) | 128 (64) | – | 39 (19) | 22 (11) | 8 (4) |
| Yang X | Lancet Respir | China | Jinyintan Hospital, Wuhan | 52 | 35 (67) | 60 (13) | 35 (67) | 2 (4) | – | 9 (17) | 5 (10) |
| Yuan M | PLoS One | China | Central Hospital of Wuhan | 27 | 10 (41) | 60 (47–69) | 12 (45) | – | 5 (19) | 6 (22) | 3 (11) |
| Zhang L | Ann Oncol | China | Tongji Sino-French New Town Hospital, Union Red Cross Hospital and Union West Hospital | 28 | 15 (54) | 65 (56–70) | 17 (61) | – | – | 4 (14) | 4 (14) |
| Zhou F | Lancet | China | Jinyintan Hospital and Wuhan Pulmonary Hospital | 191 | 59 (31) | 56 (46–67) | 119 (62) | 11 (6) | 58 (30) | 36 (19) | 15 (8) |
All studies were published in 2020.
Abbreviations: COVID-19: coronavirus disease 2019; CVD: cardiovascular disease; DM: diabetes; HTN: hypertension; NR, not reported.
* Current or former smoking.