. Author manuscript; available in PMC: 2021 Nov 1.

Published in final edited form as: AIDS Behav. 2020 Nov;24(11):3264–3278. doi: 10.1007/s10461-020-02900-7

Table 6.

Parameter estimates for change in outcomes over time

Study outcome^a		Tests of linear trends
	Time period	Estimate (SE)	LRT^a
Wisepill adherence
Active treatment	Weekly (baseline to 4-month)	0.14 (0.44)	χ²(2) = 22.15^**
Follow up	Weekly (4-month to 8-month)	− 1.33 (0.69)	χ²(2) = 56.42^**
Self-report adherence
Active treatment	Weekly (treatment phase)	0.06 (0.02)^**	χ²(2) = 1.81
Full study period	Major assessments only	0.87 (0.30)^**	χ²(2) = 5.18
Positive affect
Active treatment	Weekly (treatment phase)	0.16 (0.11)	χ²(2) = 29.24^**
Negative affect
Active treatment	Weekly (treatment phase)	− 0.28 (0.06)^**	χ²(2) = 1.26

Study outcome^b	Non-linear comparisons
	Baseline vs. 4-month	Baseline vs. 8-month
Log PVL	− 1.13 (0.30)^**	− 0.93 (0.32)^**
Positive affect	3.43 (1.77)	3.84 (1.80)^*
Negative affect	− 4.34 (1.35)^**	− 0.77 (1.37)
PHQ depression	− 1.87 (1.03)	− 1.60 (1.05)

The HLM parameter estimates are reported, followed by the standard error in parentheses

The results of the LRT determine whether we retained a fixed effects only model or if we retained the random effects as well for the linear test. A significant finding on the LRT means that we included the fixed and random effects in the linear test

Reference = baseline

Significant at p < .05

^**

Significant at p < .01