Table 1. . Clinical characteristics of 14 relapsed or refractory diffuse large B-cell lymphoma patients.
n | Gender | Age | Diagnosis | Disease status before ASCT | Sites of active disease | Conditioning therapy | MNC cell dose (×108/kg) |
CD34 cell dose (×106/kg) |
CAR T-cell dose (×106/kg) |
CRS max grade | Best response | Duration of best response (month) |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | F | 47 | DLBCL | SD | Multiple LN | CEAC | 4.60 | 0.44 | 0.74 | 1 | CR | 2.43 |
2 | F | 52 | DLBCL | SD | Multiple LN | CEAC | 4.61 | 1.15 | 3 | 1 | CR | 8.31+ |
3 | M | 32 | DLBCL | PD | Pelvic LN | CEAC | 7.14 | 1.14 | 1.2 | 2 | PD | 1.35 |
4 | M | 68 | DLBCL | SD | Abdomen LN | CEAC | 5.94 | 2.37 | 2.14 | 1 | CR | 20.4+ |
5 | M | 44 | DLBCL | PD | Abdomen LN | R-CEAC | 8.45 | 12.26 | 0.88 | N | PD | 3.65 |
6 | M | 28 | DLBCL | Relapse | Multiple LN | CEAC | 5.06 | 5.06 | 7.89 | 2 | CR | 16.07+ |
7 | F | 56 | DLBCL | PD | Breast | CEAC | 3.60 | 4.11 | 2.37 | 2 | PR | 14.82 |
8 | M | 22 | DLBCL | SD | Cervical LN | R-CEAC | 4.72 | 1.65 | 1.5 | 1 | PD | 5.62 |
9 | F | 44 | DLBCL | SD | Abdomen LN | R-CEAC | 4.70 | 12 | 2.49 | N | PR | 9.88+ |
10 | M | 27 | DLBCL | PD | Mediastinum | R-CEAC | 4.50 | 7 | 1.72 | 2 | PR | 11.4+ |
11 | F | 37 | DLBCL | SD | Abdomen LN | R-CEAC | 3.51 | 2.12 | 5 | 3 | CR | 10.91+ |
12 | M | 19 | DLBCL | PD | Multiple LN | CEAC | 7.54 | 2.76 | 6.32 | 2 | CR | 7.75+ |
13 | M | 39 | DLBCL | SD | Abdomen LN | CEAC | 5.69 | 6.67 | 3.59 | 1 | PR | 6.6+ |
14 | M | 56 | DLBCL | PD | Mediastinum | R-CEAC | 8.72 | 5.6 | 3 | 2 | PR | 1.81 |
ASCT: Autologous hematopoietic stem cell transplantation; CAR: Chimeric antigen receptor; CEAC: Semustine, cytarabine, etoposide and cyclophosphamide; CR: Complete remission; CRS: Cytokine-release syndrome; DLBCL: Diffuse large B-cell lymphoma; F: Female; LN: Lympho nod; M: Male; MNC: Mononuclear cell; N: No CRS; PD: Progressive disease; PR: Partial remission; R: Rituximab; SD: Stable disease.