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. Author manuscript; available in PMC: 2020 Oct 9.
Published in final edited form as: Br J Haematol. 2017 Oct 18;179(4):618–626. doi: 10.1111/bjh.14953

Table II.

Effect of sex, age, race/ethnicity, marital status, insurance status and year of diagnosis on survival in pre-B ALL from 2010 to 2014

N Median OS (95% CI), months HR (95% CI) Log-rank test P value Adjusted HR (95% CI)* Wald test P value*
Sex
 Male 1479 28 (24, 33) Reference 0·47 Reference 0·39
 Female 1215 27 (22, 32) 1·04 (0·93, 1·17) 0·95 (0·84, 1·07)
Age at diagnosis, years
 18–39 917 NE (58, NE) Reference <0·001 Reference <0·001
 40–49 420 33 (25, NE) 1·50 (1·24, 1·82) 1·58 (1·30, 1·93)
 50–59 503 23 (18, 33) 1·78 (1·49, 2·12) 1·92 (1·59, 2·32)
 60–69 471 20 (16, 23) 2·18 (1·84, 2·59) 2·48 (2·06, 2·99)
 70+ 383 8 (6, 10) 3·84 (3·24, 4·55) 4·74 (3·93,5·72)
Race/ethnicity
 Non-Hispanic White 1367 28 (24, 33) Reference 0·090 Reference 0·009
 African American 173 21 (16, 27) 1·14 (0·91, 1·43) 1·43 (1·13, 1·83)
 Asian 194 NE (24, NE) 0·78 (0·61, 1·00) 0·93 (0·70, 1·23)
 Hispanic 928 26 (22, 33) 0·94 (0·82, 1·06) 1·22 (1·04, 1·43)
 Native American 28 17 (10, NE) 1·21 (0·73, 2·03) 1·56 (0·91, 2·68)
 Unknown 4 NE NE NE
Married
 Yes 1323 34 (28, 42) Reference 0·003 Reference 0·19
 Not 1371 23 (21, 27) 1·19 (1·06, 1·33) 1·09 (0·96, 1·23)
 Insurance <0·001
 Insured 1812 28 (24, 33) Reference 0·60 Reference
 Any medicaid 675 25 (20, 31) 1·06 (0·92, 1·21) 1·40 (1·20, 1·64)
 Uninsured/unknown 207 30 (21, NE) 0·95 (0·76, 1·19) 1·25 (0·99, 1·58)
Year of diagnosis
 2010 529 23 (18, 30) Reference 0·18 Reference 0·33
 2011 553 28 (23, 33) 0·90 (0·77, 1·05) 0·94 (0·80, 1·10)
 2012 526 28 (23, NE) 0·90 (0·76, 1·06) 0·92 (0·78, 1·09)
 2013 542 NE 0·89 (0·75, 1·07) 0·88 (0·74, 1·06)
 2014 544 NE 0·76 (0·59, 0·98) 0·77 (0·60,0·99)
Ph status
 Ph+ 206 32 (18, NE) Reference 0·34 Reference 0·63
 Ph− 2488 27 (24, 30) 1·12 (0·88, 1·42) 1·06 (0·83, 1·37)

CI, confidence interval; HR, hazard ratio; NE, not reached or not evaluable.

*

Based on the Cox multivariate regression model adjusted variables included in the table and stratified by SEER registry site.