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. 2020 Oct 9;183(5):1354–1366.e13. doi: 10.1016/j.cell.2020.10.005

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© 2020 Elsevier Inc.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Proinflammatory Cytokines, ISGs, IFNα, and Complement Cascade Genes Correlated with SARS-CoV-2 Viral Loads in BAL of Infected Macaques

(A) The expression of cytokines, ISGs, IFNα, and complement correlated with day 2 viral loads in BAL. The x axis corresponds to gene raw read counts and the y axis corresponds to log10 SARS-CoV-2 RNA copies/mL in BAL. A Spearman correlation was used for statistical analysis.

(B) The expression of additional cytokines, chemokines, and ISGs correlated positively with viral loads in BAL on days 1, 2, 4, 7, and 10 post SARS-CoV-2 challenge. Colored lines connecting genes with time points represent the Spearman correlation between the expression of each gene with viral loads across all animals for the same time point. For clarity, each time point was shown in a different color.