FIGURE 6.

FLNA silencing significantly increases viral replication while FLNA over-expression significantly impairs viral replication. (A) Supernatant from siRNA treated and IAV PR8 infected A549 cells were collected 24 h.p.i to perform plaque assay on MDCK cells. The data show mean ± S.D. from one representative FLNA silencing experiment (n = 3). Statistical significance was determined using Student’s t test (^∗p < 0.05). (B) Supernatant from plasmid treated and IAV PR8 infected HEK293 cells were collected 24 h.p.i to perform plaque assay on MDCK cells. The data show mean ± S.D. from one representative FLNA over-expression experiment (n = 3). Statistical significance was determined using Student’s t test (^∗p < 0.05).