| CDX Family |
all |
master regulator of HOX family gene (Frohling et al., 2007; Rawat, Humphries & Buske, 2012; Shiotani et al., 2008) |
| CDK Family |
CDK1, CDK2, Cdc5 |
master regulator of cell cycle regulation (Botchkarev & Haber, 2018; Hinds, 2003; Satyanarayana & Kaldis, 2009) |
| HSFs Family |
HSF1, HSF2, HSFA1 |
master regulator of heat shock reaction (Filone et al., 2014; Liu & Charng, 2012; Qiao et al., 2017; Shinkawa et al., 2011
|
| MTA Family |
all |
master regulator of the occurrence and metastasis of cancer (Du et al., 2017; PA, 2014; Zhu et al., 2009) |
| SREBP Family |
all |
master regulator of lipid homeostasis (Gong et al., 2016; Krycer et al., 2010; Madison, 2016) |
| Rho Family |
Including RhoA, Rac1 and Cdc42 proteins, and so on |
master regulator for a large number of cell functions, including control of cell morphology, cell migration and polarity, transcriptional activation and cell cycle progression (Bai et al., 2015; Colomba & Ridley, 2014; Costa et al., 2011; PA, 2014; Singh et al., 2019; Watanabe, Takano & Endo, 2006; Zago et al., 2019) |
| HNF (Hepatocyte nuclear factor) Family |
IncludingHNF1A/B, HNF4alpha, HNF6 |
master regulator of pancreas and liver differentiation (Alder et al., 2014; Janky et al., 2016; Kondratyeva et al., 2017; Odom et al., 2004; Sandovici et al., 2013) |
| IL(interleukin) Family |
Including IL-1, IL-2, IL-6, IL-7, IL-10, IL-12, IL-21, IL-23, IL-27, ILC3, and so on |
master regulator of inflammation or immunity (Fry & Mackall, 2001; Langrish et al., 2004; Neurath, 2007; Qin et al., 2017; Rojas et al., 2017; Sharma, Fu & Ju, 2011; Waldner & Neurath, 2014; Wilson & Esposito, 2009; Zhou & Sonnenberg, 2020) |
| Rab GTPases Superfamily |
Including Rab5, Rab7b, Rab11 GTPase, and so on |
master regulator of cell membrane transport (Distefano et al., 2015; Ishida, E. Oguchi & Fukuda, 2016; Pfeffer, 2017; Qi et al., 2015; Wu et al., 2015) |
| The MiTF/TFE Family of Transcription Factors |
MITF, TFEB, TFE3, TFEC |
Master Regulators of Organelle Signaling, Metabolism, and Stress Adaptation (Slade & Pulinilkunnil, 2017) |
| PLK Family |
all |
master regulator of cell division |
| PLK1 |
master regulator of mitotic related kinases (Combes et al., 2017) |
| PLK4 |
master regulator of the formation of centrioles (Levine & Holland Andrew, 2014; Shaheen et al., 2014) |
| PAX Family |
all |
master regulator of development and tissue homeostasis (Relaix, 2015) |
| Pax5 |
master regulator of b-cell development and leukemia (Medvedovic et al., 2011; Nebral et al., 2009) |
| Pax6 |
master regulator of ganglion cells of the retina and eye development (Albert et al., 2013; Shubham & Mishra, 2012) |
| TBX Family |
TBX1 |
master regulator of muscle differentiation (Chen et al., 2009) |
| TBX5 |
master regulator of heart development (Boogerd & Evans, 2016) |
| TBX21 |
master regulator of Th1 cell development (Nicol et al., 2016; Stolarczyk, Lord & Howard, 2014; Wilkie et al., 2016) |
| SOX Family |
SOX2 |
master regulator of mammalian embryogenesis, embryonic stem cell self-renewal and pluripotency (Rizzino, 2008; Whyte et al., 2013) |
| SOX3 |
master regulator of innate immunity (Doostparast Torshizi & Wang, 2017) |
| SOX4 |
master regulator of EMT (epithelial-mesenchymal transition) (Lourenço & Coffer, 2017; Tiwari et al., 2013) |
| SOX5, SOX6 |
the interaction with SOX9 is a master regulator of cartilage development (Ma et al., 2016; Suzuki et al., 2012; Vivekanandan et al., 2015) |
| SOX9 |
master regulator of testis differentiation pathway (Jakob & Lovell-Badge, 2011; Mork & Capel, 2010; Kozhukhar, 2012) |
| master regulator of fibroblast differentiation (Noizet et al., 2016) |
| master regulator of pancreatic program (Julian, McDonald & Stanford, 2017; Seymour, 2014) |
| SOXB1, SOXE, SOXF |
master regulator of cell fate (Julian, McDonald & Stanford, 2017) |
| RUNX Family |
RUNX1 |
master regulator of adult hematopoiesis (Ichikawa et al., 2004; Wehrspaun, Haerty & Ponting, 2015; Wu et al., 2014) |
| RUNX2 |
master regulator of osteoblast lineage (Liu et al., 2017; Wysokinski, Pawlowska & Blasiak, 2015) |
| IRF Family |
IRF-1 |
master regulator of cross talk between macrophage and L929 fibrosarcoma cells (Nascimento et al., 2015) |
| IRF4 |
master regulator of human periodontitis (Sawle et al., 2016) |
| IRF7 |
master regulator of IFN-I, virus-induced cytokine (Hu et al., 2011; Lu et al., 2015; Wang et al., 2013) |
| IRF8 |
master regulator of monocytes and dendritic cells development (Tamura, 2017) |
| BCL Family |
BCL-2 |
master regulator of apoptosis (Chen et al., 2012; Häcker & Vaux, 1995) |
| BCL-6 |
master regulator of Tfh cell differentiation (Matsumoto et al., 2017) |
| BCL11B |
master regulator of T cell (Th) differentiation (Inoue et al., 2016) |
| BCL–2–like 10 |
master regulator of Aurora kinase a mouse oocytes (Lee et al., 2016) |
| C/EBP Family |
C/EBPα
|
master regulator of the bone marrow progenitor cells and fat formation (Ding et al., 2011; Okuno, Inoue & Imai, 2013) |
| C/EBPbeta |
master regulator of physiological cardiac hypertrophy (Molkentin Jeffery, 2011) |
