Table 2.
Study procedures for eligible patients with AIS.
| Time points | Prehospital | Admission | 24 h | 3 days | 5 days | 3 months |
|---|---|---|---|---|---|---|
| Enrollment | ||||||
| Eligibility screen | ✓ | |||||
| Patient/family information | ✓ | ✓ | ||||
| Acute waiver of consent | ✓ | |||||
| Randomization | ✓ | |||||
| RACE scale | ✓ | |||||
| Blood pressure | ✓ | ✓‡ | ||||
| Informed consent | ✓ | |||||
| AIS confirmation | ✓* | ✓* | ||||
| Demographics and medical history | ✓ | |||||
| Reperfusion therapies | ✓ | |||||
| Intervention | ||||||
| RIC/Sham application | ✓ | |||||
| Complications related to RIC | ✓ | ✓ | ✓ | ✓ | ||
| Assessment | ||||||
| NIHSS | ✓ | ✓ | ✓ | ✓ | ||
| Modified Rankin scale | ✓ | ✓ | ✓ | |||
| Neuroimaging | ✓ | ✓# | ||||
| MRI | ✓ | |||||
| Blood biomarkers | ✓ | ✓ | ✓ | |||
| Stroke etiology | ✓ | |||||
| Quality of life | ✓ | |||||
| Neuropsychological evaluation | ✓ | |||||
| Safety measurement | ||||||
| Intrahospital complications | ✓ | ✓ | ||||
| SICH | ✓ | ✓ |
RACE, rapid arterial occlusion evaluation; AIS, acute ischemic stroke; RIC, remote ischemic conditioning; MRI, magnetic resonance imaging; NIHSS, National Institutes of Health Stroke Scale.
‡
Blood pressure will be reported at the end of RIC/Sham application and 1 h after.
*
Patients with intracranial hemorrhage will complete the 90 days follow-up. Patients without evidence of brain ischemia will be followed until discharge and through registries.
#
Patients treated with intravenous rtPA and/or EVT will undergo neuroimaging at 24 h.