Table 4.

Univariable and multivariable regression analysis of risk of miscarriage, preterm delivery and pregnancy-induced hypertension.

Outcomes	Variables	OR (95% CI)	P-value	Adjusted OR(95% CI)a	P-valuea	Adjusted OR(95% CI)b	P-valueb
Miscarriage	PCOS diagnosis	1.571 (1.210−2.039)	0.001	1.585 (1.210−2.078)	0.001	1.629 (1.240−2.141)	<0.001
	Maternal age (y)	1.070 (1.043−1.098)	<0.001	1.069 (1.042−1.098)	<0.001	1.037 (1.007−1.067)	0.015
	Maternal BMI (kg/m2)	1.072 (1.040−1.106)	<0.001	1.051 (1.018−1.086)	0.002	1.046 (1.012−1.080)	0.008
	Infertility duration (y)	1.054 (1.019−1.089)	0.002			1.021 (0.986−1.057)	0.237
	Serum E2 level (pg/ml) on hCG day2	0.925 (0.871−0.982)	0.010			0.945 (0.890−1.004)	0.069
	EMT (mm) on hCG day	0.953 (0.917−0.991)	0.015			0.949 (0.912−0.987)	0.009
	No. of embryos transferred	1.473 (1.296−1.674)	<0.001			1.348 (1.160−1.565)	<0.001
	Embryo type
	Cleavage embryo	Ref	Ref			Ref	Ref
	Blastocyst	0.566 (0.393−0.817)	0.002			0.693 (0.472−1.017)	0.061
	Embryo quality
	Cycle with high-quality embryos	Ref	Ref			Ref	Ref
	Cycles without high-quality  embryos	1.887 (1.133−3.143)	0.015			1.846 (1.098−3.104)	0.021
Preterm delivery (< 37 weeks)	PCOS diagnosis	1.288 (1.012−1.639)	0.040	1.236 (0.966−1.582)	0.092	1.187 (0.922−1.528)	0.185
	Maternal age (y)	0.985 (0.964−1.006)	0.158	0.985 (0.964−1.007)	0.172	0.969 (0.946−0.992)	0.009
	Maternal BMI (kg/m2)	1.016 (0.989−1.044)	0.243	1.015 (0.987−1.044)	0.285	1.015 (0.986−1.044)	0.318
	Total dose of gonadotropin (IU)1	0.903 (0.821−0.994)	0.037			0.933 (0.841−1.036)	0.194
	No. of fertilized occytes	1.017 (1.002−1.032)	0.023			1.010 (0.994−1.026)	0.215
	No. of embryos transferred	1.209 (1.075−1.359)	0.002			1.428 (1.252−1.628)	<0.001
	Embryo type
	Cleavage embryo	Ref	Ref			Ref	Ref
	Blastocyst	1.622 (1.285−2.047)	<0.001			1.964 (1.534−2.514)	<0.001
	Pregnancy-induced hypertension	2.468 (1.621−3.757)	<0.001			2.439 (1.595−3.731)	<0.001
Preterm delivery (< 32 weeks)	PCOS diagnosis	2.448 (1.375−4.358)	0.002	2.135 (1.170−3.895)	0.013	2.072 (1.133−3.791)	0.018
	Maternal age (y)	0.934 (1.003−1.071)	0.934	1.002 (0.937−1.072)	0.948	1.000 (0.935−1.069)	0.997
	Maternal BMI (kg/m2)	1.114 (1.032−1.204)	0.006	1.094 (1.010−1.184)	0.028	1.089 (1.006−1.179)	0.035
	Pregnancy-induced hypertension	3.132 (1.233−7.953)	0.016			2.727 (1.059−7.020)	0.038
Pregnancy-induced hypertension	PCOS diagnosis	1.842 (1.049−3.234)	0.034	1.784 (0.996−3.197)	0.052	1.764 (0.981−3.171)	0.058
	Maternal age (y)	1.042 (0.982−1.106)	0.171	1.043 (0.981−1.108)	0.177	1.017 (0.955−1.084)	0.595
	Maternal BMI (kg/m2)	1.077 (1.003−1.156)	0.040	1.057 (0.982−1.137)	0.143	1.032 (0.958−1.111)	0.412
	Infertility duration (y)	1.098 (1.023−1.178)	0.010			1.081 (1.003−1.165)	0.042
	Serum E2 level (pg/ml) on hCG day2	0.803 (0.683−0.945)	0.008			0.824 (0.700−0.969)	0.020

All the variables inputted in the model were shown in Table 4. BMI, body mass index; CI, confidence interval; OR, odds ratio; E₂, estradiol; hCG, human chorionic gonadotropin; EMT, endometrial thickness; Ref, reference; ¹per 1,000 IU increased; ²per 1,000 pg/ml increased.

^aAdjusted for maternal age and BMI.

^bAdjusted for maternal age, BMI, and other variables based on the univariate logistic regression model.