Table 1.
Characteristics of the 20 included animal studies.
| Study (years) | Species (Sex, experimental/control group) | Weight | Modeling approach | Anesthetic | Treatment group | Control group | Outcome measure | Intergroup differences |
|---|---|---|---|---|---|---|---|---|
| Zhang et al., 2017b | Male sprague-dawley rats(10/15) | 240–260 g | Rotenone | – | Baicalein (100, 200, 400 mg/kg p.o.) | – | Spontaneous motor activity test Rotarod test TH |
P < 0.05 P < 0.05 P < 0.01 |
| Hung et al., 2016 | Male sprague-dawley rats (-/-) | 300–350 g | MPP+ | Chloral hydrate | Baicalein (10 and 30 mg/kg) | 10% DMSO in saline | DA TH IL-1β ED-1 a-Caspase 1 Cathepsin B |
P < 0.05 P < 0.05 P < 0.05 P < 0.05 P < 0.05 P < 0.05 |
| Mu et al., 2009 | Male sprague-dawley rats(12/12) | 180–200 g; | 6-OHDA | 3% sodium pentobarbital (45 mg/kg i.p.) | Baicalein (200 mg/kg; i.g.) | Saline i.g. | Apomorphine-induced rotation test Tremor test -Burst frequency -Burst amplitude TH GFAP |
P > 0.05 P < 0.01 P < 0.01 P < 0.05 P < 0.01 |
| Cheng et al., 2008 | Male C57BL/6 mice (10/10) | ~25 g | MPTP | – | Baicalein (200 mg/kg; i.g.) | Saline i.g. | Spontaneous motor activity test Pole test DA DOPAC 5-HT 5-HIAA TH GFAP SOD GSH-Px MDA |
P < 0.05 P < 0.05 P < 0.01 P > 0.05 P < 0.05 P > 0.05 P < 0.05 P < 0.01 P < 0.05 P < 0.05 P < 0.05 |
| He et al., 2015 | Male sprague-dawley rats(12/12) | 180–200 g | 6-OHDA | 3% sodium pentobarbital (50 mg/kg i.p.) | Baicalein (200 mg/kg i.g.) | Distilled water i.g. | Spontaneous motor activity test Apomorphine-induced rotation test Tremor test -Burst frequency -Burst amplitude DA DOPAC TH |
P < 0.05 P < 0.01 P < 0.05 P < 0.01 P < 0.05 P > 0.05 P < 0.05 |
| Li, 2011 | Male sprague-dawley rats (−/−) | 180–200 g | 6-OHDA | 3% sodium pentobarbital (50 mg/kg i.p.) | Baicalein (200 mg/kg; i.g.) | – | Spontaneous motor activity test Rotarod test Apomorphine-induced rotation test Tremor test-burst frequency DA DOPAC 5-TH 5-HIAA GABA GLU E TH GFAP |
P < 0.05 P < 0.05 P < 0.01 P < 0.001 P > 0.05 P < 0.05 P > 0.05 P > 0.05 P > 0.05 P > 0.05 P > 0.05 P < 0.05 P < 0.05 |
| Mu et al., 2011 | Male C57BL/6 mice (12/12) | ~25 g | MPTP | – | Baicalein (140, 280, 560 mg/kg i.g.) | Saline i.g. | Spontaneous motor activity test Rotarod test DA DOPAC TH SOD GSH-P x MDA |
P < 0.05 P < 0.05 P < 0.05 P > 0.05 P < 0.05 P < 0.05 P < 0.05 P < 0.05 |
| Gao et al., 2015 | Male C57BL/6 mice (15/15) | – | MPTP | – | Baicalein (140 and 280 mg/kg i.g.); | Saline i.g. | Pole test Rotarod test |
P < 0.001 P < 0.01 |
| Im et al., 2005 | Male ICR mice (−/−) | 26–28 g | 6-OHDA | – | Baicalein (25 and 50 mg/kg, i.p) | 5% DMSO | Rotarod test DA DOPAC TH MDA |
P < 0.05 P < 0.05 P < 0.05 P < 0.05 P < 0.05 |
| Xue et al., 2014 | Male C57BL/6 mice (−/−) | 18–24 g | MPTP | halothan | Baicalein (10 mg/kg, i.p.) | Saline i.p. | Rotarod test TNF-a IL-1β |
P < 0.05 P < 0.05 P < 0.05 |
| Lee et al., 2014 | Male C57BL/6 mice (−/−) | 20–23 g | MPTP | Ethyl ether | Baicalein (1 and 10 mg/kg i.p.); | PBS containing 5% ethanol and 2% Tween 20 i.p. | Rotarod test TH |
P < 0.01 P < 0.01 |
| Hu et al., 2016 | Male C57BL/6 mice (−/−) | – | Rotenone | – | Baicalein (100 mg/kg; i.p.) | – | Rotarod test Grid test DA DOPAC TH |
P < 0.01 P < 0.01 P < 0.01 P < 0.01 P < 0.05 |
| Kuang et al., 2017 | Male C57BL/6 mice (−/−) | – | Rotenone | – | Baicalein (100 mg/kg; i.p.) | – | Rotarod test Grid test DA |
P < 0.01 P < 0.01 P < 0.01 |
| Im et al., 2006 | Male ICR mice (−/−) | 26–28g | 6-OHDA | Equithesin (0.6 mg/ml, 5 ml/kg, i.p.) | Baicalein (25 and 50 mg/kg, i.p) | 5% DMSO | Apomorphine-induced rotation test DA DOPAC MDA TH |
P < 0.05 P < 0.05 P < 0.05 P < 0.05 P < 0.05 |
| Yu et al., 2012 | Male sprague-dawley rats(12/12) | 180–200 g | 6-OHDA | Sodium pentobarbital (45 mg/kg i.p.); Chloralose (300 mg/kg, i.p.) | Baicalein (100, 200 and 400 mg/kg i.g.); | Saline i.g. | Tremor test -Burst frequency -Burst amplitude DA GABA GLU |
P < 0.01 P < 0.001 P > 0.05 P < 0.05 P < 0.05 |
| Yang et al., 2018 | Male KM mice (8/8) | 18–22 g | Oxotremorine | – | Baicalein (120, 240, 480 mg/kg i.g.) | Saline i.g. | DA DOPAC E GSH-P x MDA |
P < 0.01 P < 0.01 P > 0.05 P > 0.05 P > 0.05 |
| Zhao et al., 2018 | Male sprague-dawley rats (−/−) | 300–350 g | Acrolein | Chloral hydrate (450 mg/kg) | Baicalein (30 mg/kg) | 10% DMSO in saline | ED-1 a-Caspase 1 Cathepsin B DA IL-1β GFAP |
P < 0.05 P < 0.05 P < 0.05 P < 0.05 P < 0.05 P < 0.05 |
| Han et al., 2019 | Male Sprague–Dawley rats(12/12) | 200 ± 20 g | Rotenone | Chloral hydrate (300 mg/kg) | Baicalein (200 mg/kg s.c.) | Saline s.c. | TH | P < 0.01 |
| Zheng et al., 2019 | Male C57BL/6 mice (6/6) | 25–30 g | MPTP | – | Baicalein (10 mg/kg i.p.) | Saline | TH | P > 0.05 |
| Zhang et al., 2017a | Male Sprague-Dawley rats(10/10) | 240–260 g | Rotenone | – | Baicalein (100, 200, 400 mg/kg p.o.) | – | GFAP TNF-a IL-1β |
P < 0.01 P < 0.05 P > 0.05 |