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. 2020 Sep 25;11:574027. doi: 10.3389/fimmu.2020.574027

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Copyright © 2020 Rich, Antos, Melton, Alcorn and Manni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Type I and III interferon induction and T helper cell response to respiratory pathogens in the asthmatic lung. Type I and III IFNs are known to have overlapping innate and adaptive roles in the lung and decreased IFN response to respiratory infection in asthmatics is thought to contribute to acute exacerbations. Cross-inhibition between type 2 responses and type I and III IFNs have been reported in the context of type 2-high asthma and acute viral exacerbations. Type I and III IFNs also can alter Th1 and Th17 responses and may directly and indirectly influence type-2 low asthma and exacerbations of disease. Further, pathogens can influence T helper cell responses independent of IFN as well, directly altering the inflammatory environment in the asthmatic lung. Figure created in BioRender.com.

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