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. Author manuscript; available in PMC: 2020 Oct 9.
Published in final edited form as: J Invest Dermatol. 2018 Nov 2;139(4):859–867. doi: 10.1016/j.jid.2018.07.046

Figure 5. Topical application of siRNA suppresses Pcsk9 and reduces IMQ-induced psoriasis-like reactions.

Figure 5.

(a, b) Quantification of Pcsk9 mRNA and protein expression in the si-Pcsk9 transfected skin (48 hours after the treatment) and the controls. *P < 0.05, t test. (c) Western blot image. (d) Representative photos of dorsal skin in si-Con and si-Pcsk9 mice after 5 days of IMQ treatment. (e) Scores of erythema, scaling, thickness, and total scores of si-Con and si-Pcsk9 mice during IMQ treatment. *P < 0.05, t test. Con, control; IMQ, imiquimod; siRNA, small interfering.