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. 2020 Oct 9;15(10):e0240562. doi: 10.1371/journal.pone.0240562

Fig 6. Mitochondrial integrity after compound treatment.

Fig 6

The integrity of mitochondria in the liver were assessed by EM and photomicrographs were taken at 10,000X (A-D, bar = 600nm or 15,000X (E,F, bar = 400 nm) magnification. Representative images from APAP-vehicle (A), APAP (B), FS-vehicle (C) and FS (D) dosed mice are shown. Both APAP and FS-dosed animals exhibited megamitochondria and electron dense areas in the mitochondrial matrix (arrow head). FS dosed animals also exhibited swollen mitochondria with dispersion of mitochondrial matrix and blunted cristae (E) and mitochondria within vesicles (F). Abbreviations: M, mitochondria; RER, rough endoplasmic reticulum.