Table 3. Proportions of newborns with congenital CMV infection with and without hearing loss by age 18 years of age, and type of maternal CMV infection.
| Symptomatic | Asymptomatic | Control | Row Totals | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hearing Loss (HL) | HL/n | Proportion (95% CI) | p | HL/n | Proportion (95% CI) | p | HL/n | Proportion (95% CI) | p | HL/n | Proportion (95% CI) | p |
| Primary | 9/12 | 75.0% | .009 | 14/51 | 27.5% | .157 | 1/10 | 10.0% | .462 | 24/73 | 32.9% | < .001 |
| (0.0–28.6) | (22.1–43.7) | |||||||||||
| (50.5–99.5) | (15.2–39.7) | |||||||||||
| non-Primary | 0/4 | 0 | 2/18 | 11.1% | 0/5 | 0 | 2/27 | 7.4% | ||||
| (0.0–25.6) | (0.0–17.3) | |||||||||||
| No Infection | - | - | - | - | 1/10 | 10.0% | 1/10 | 10.0% | ||||
| (0.0–28.6) | ||||||||||||
| (0.0–28.6) | ||||||||||||
| Unknown | 48/61 | 78.7% | 6/40 | 15% | 1/26 | 3.8% | 55/127 | 43.3% | ||||
| (68.4–89.0) | (3.9–26.1) | (0.0–11.2) | (34.7–51.9) | |||||||||
| Column Totals | 57/77 | 74.0% | 22/109 | 20.2% | 3/51 | 5.9% | 82/237 | 34.6% | ||||
| (0.0–12.3) | (28.5–40.7) | |||||||||||
| (64.2–83.8) | (12.6–27.7) | |||||||||||
| Trimester of Infection (Primary Infections Only): | ||||||||||||
| 1st | 2/3 | 66.7% | 3/9 | 33.0% | 0/4 | 0.0% | 5/16 | 31.3% | ||||
| (13.3–1.00) | (2.5–64.1) | (8.5–54.0) | ||||||||||
| 1st or 2nd | 0/0 | 0.0% | 1 / 2 | 50% | 0/0 | 0% | 1/2 | 50.0% | ||||
| (0.0–1.0) | ||||||||||||
| (0.0–1.0) | ||||||||||||
| 2nd | 1/1 | 100% | 3/11 | 27.3% | 0/0 | 0% | 4/12 | 33.3% | ||||
| (1.0–1.0) | (0.1–53.6) | (6.7–60.0) | ||||||||||
| 2nd or 3rd | 2/2 | 100% | 2/6 | 33.3% | 0/0 | 0% | 4/8 | 50.0% | ||||
| (15.4–84.6) | ||||||||||||
| (1.0–1.0) | (0.0–71.1) | |||||||||||
| 3rd | 3/3 | 100% | 5/20 | 25.0% | 1/5 | 20.0% | 9/28 | 32.1% | ||||
| (6.0–44.0) | (0.0–55.1) | (14.8–49.4) | ||||||||||
| (1.0–1.0) | ||||||||||||
| Unknown | 1/3 | 33.3% | 0/3 | 0.0% | 0/1 | 0.0% | 1/7 | 14.3% | ||||
| (0.0–86.7) | (0.0–40.2) | |||||||||||
| Totals | 9/12 | 75% | 14/51 | 27.5% | 1/10 | 10.0% | 24/73 | 32.9% | ||||
| (15.2–39.7) | (0.0–28.6) | (22.1–43.7) | ||||||||||
| (50.5–99.5) | ||||||||||||
| Pregnancy Half When Infected (Primary Infections Only) | ||||||||||||
| First Half of Pregnancy | 3/4 | 75% | .444 | 5/15 | 33.3% | .669 | 0/4 | 0.0% | 1.000 | 8/23 | 34.8% | .858 |
| (32.6–1.0) | (9.5–57.2) | (15.3–54.2) | ||||||||||
| Second Half of Pregnancy | 5/5 | 100% | 9/33 | 27.3% | 1/5 | 20.0% | 14/43 | 32.6% | ||||
| (1.0–1.0) | (12.1–42.5) | (0.0–55.1) | (18.6–46.6) | |||||||||
| Unknown | 1/3 | 33.3% | 0/3 | 0% | 0/1 | 0% | 1/7 | 14.3% | ||||
| (0.0–86.7) | (0.0–40.2) | |||||||||||
| Totals | 8/12 | 75.0% | 14/51 | 27.5% | 1/10 | 10.0% | 23/73 | 31.5% | ||||
| (40.0–93.3) | (20.9–42.2) | |||||||||||
| (15.2–39.7) | (0.0–28.6) | |||||||||||