a-b, Low-pass filtered sub-particle reconstructions of eBV CATC-binding penton vertex (a) and of KSHV CATC-binding penton vertex (eMD-20433) (b). c, Superposition of (a) and (b) showing that eBV and KSHV CATC structures differ in two aspects: First, CVC2 head domain in KSHV heads right, as opposite to that in eBV, which heads left; Second, their helix bundles have an ~30º angle difference.