Table 1.

Study Definitions.

Consensus Diagnosis: Cognitively Unimpaired (CU)
Grouped by Future Diagnosis	Grouped by Biomarker Profile (AT)1
CU Stable2 (n = 450)	CU A−T− (n = 146)
CU Converter3 (n = 150)	CU A+T− (n = 61)
	CU A+T+ (n = 33)
sOBJ Exploring the utility of possible definitions of cross-sectional subtle objective cognitive impairment (sOBJ)
1. Cogstate Brief Battery Lrn/WM Composite4 ≤ −1 SD
2. AVLT 30-Minute Delay5 ≤ −1 SD

¹Biomarker profile defined by neuroimaging biomarkers of amyloid and tau within two years of baseline Cogstate.

²CU at baseline Cogstate and remained CU at all available follow-up visits. N=51 participants with biomarker data were also represented in this group (n=29 CU A−T−, n=14 CU A+T−, n = 8 CU A+T+).

³CU at baseline Cogstate and converted to MCI/dementia at any follow-up visit. N=18 participants with biomarker data were also represented in this group (n=5 CU A−T−, n=5 CU A+T−, n = 8 CU A+T+).

⁴Cogstate is independent of consensus diagnosis; ≤ −1 SD cut-off is equivalent to an age-corrected z-score of ≤ −1 derived from normative data provided by Cogstate.

⁵AVLT is considered as part of consensus diagnosis; ≤ −1 SD cut-off is equivalent to a Mayo’s Older Americans Normative Studies age-corrected scaled score of ≤ 7.

Note. CU = Cognitively Unimpaired; A = amyloid; T = tau; sOBJ = subtle objective cognitive impairment; AVLT = Auditory Verbal Learning Test 30-Minute Delayed Recall; Lrn/WM = Learning/Working Memory.