Table 2.
Demographic characteristics and mean performance on memory measures among cognitively unimpaired (CU) participants.
| CU A−T− M (SD) (n = 146) | CU A+T+ M (SD) (n = 33) | p-value CU A−T− vs A+T+ | CU A+T− M (SD) (n = 61) | p-value CU A−T− vs A+T− | p-value CU A+T− vs A+T+ | |
|---|---|---|---|---|---|---|
| Age Mean (SD) | 66.32 (12.06) | 79.52 (6.27) | < 0.001 | 77.78 (9.41) | < 0.001 | 0.341 |
| Education Mean (SD) | 15.24 (2.44) | 14.79 (3.08) | 0.362 | 14.77 (2.81) | 0.229 | 0.978 |
| Sex (% Male) | 78 (53.4%) | 20 (60.6%) | 0.454 | 37 (60.7%) | 0.340 | 0.996 |
| Short Test of Mental Status1 | 36.18 (1.99) | 35.69 (2.12) | 0.214 | 35.08 (2.31) | < 0.001 | 0.220 |
| AVLT Delay MOANS SS1 | 10.58 (2.92) | 8.82 (3.05) | 0.002 | 9.05 (2.58) | < 0.001 | 0.699 |
| Prior AVLT exposure (%) | 26.7% | 72.7% | < 0.001 | 56.7% | < 0.001 | 0.126 |
| CBB Learning/Working Memory Composite z-score | 0.22 (0.78) | −0.07 (0.98) | 0.072 | 0.06 (1.27) | 0.274 | 0.617 |
| CBB Learning/Working Memory Composite | 0.008 | 0.083 | 0.369 | |||
| Normal z > −1 | 138 (95.2%) | 27 (81.8%) | 54 (88.5%) | |||
| sOBJ z ≤ −1 | 7 (4.8%) | 6 (18.2%) | 7 (11.5%) | |||
| AVLT 30 minute delay1 | < 0.001 | 0.016 | 0.043 | |||
| Normal SS > 7 | 129 (88.4%) | 18 (54.5%) | 45 (75.0%) | |||
| sOBJ SS ≤ 7 | 17 (11.6%) | 15 (45.5%) | 15 (25.0%) | |||
Note. P-values represent linear model ANOVAs for mean comparisons or Pearson’s Chi-squared test for frequency comparisons of amyloid positive groups with the biomarker negative group. A = amyloid; T = tau; CBB = Cogstate Brief Battery; AVLT = Auditory Verbal Learning Test 30-Minute Delayed Recall; MOANS = Mayo’s Older Americans Normative Studies; SS = scaled score; sOBJ = objective subtle cognitive impairment.
1
Performance is considered as part of consensus diagnosis.