Table 3.

Diagnostic accuracy of memory measures based on derived, optimal cut-off scores and conventional cut-off scores (≤ −1 SD) indicative of subtle objective cognitive impairment (sOBJ).

Measure	Group Comparison	AUC (95% CI)	Threshold	Sensitivity (95% CI)	Specificity (95% CI)
CBB Lrn/WM composite z-score	A−T− vs A+T− among CU	0.51 (0.42,0.60)	−0.23 z	0.38 (0.26,0.51)	0.75 (0.68,0.82)
			Conventional	0.11 (0.05,0.20)	0.95 (0.92,0.99)
	A−T− vs A+T+ among CU	0.59 (0.47,0.72)	−0.06 z	0.55 (0.36,0.73)	0.68 (0.61,0.76)
			Conventional	0.18 (0.06,0.33)	0.95 (0.91,0.99)
	CU stable vs converter	0.70 (0.65,0.74)	−0.04	0.77 (0.70,0.83)	0.58 (0.53, 0.62)
			Conventional	0.25 (0.18,0.32)	0.88 (0.85,0.91)
AVLT delay MOANS Scaled Score1	A−T− vs A+T− among CU	0.64 (0.57,0.72)	11.5 SS	0.83 (0.73,0.92)	0.42 (0.34,0.50)
			Conventional	0.25 (0.15,0.37)	0.88 (0.83,0.93)
	A−T− vs A+T+ among CU	0.66 (0.56, 0.77)	7.5 SS	0.45 (0.27, 0.64)	0.88 (0.83, 0.93)
			Conventional	0.45 (0.27, 0.61)	0.88 (0.83, 0.93)
	CU stable vs converter	0.70 (0.65, 0.75)	9.5 SS	0.70 (0.63, 0.77)	0.61 (0.56, 0.65)
			Conventional	0.38 (0.31, 0.46)	0.86 (0.83, 0.89)

Note. A = amyloid; T = tau; CU = Cognitively Unimpaired; CBB = Cogstate Brief Battery; Lrn/WM = Learning/Working Memory; AVLT = Auditory Verbal Learning Test 30-Minute Delayed Recall; MOANS = Mayo’s Older Americans Normative Studies.

¹Performance is considered as part of consensus diagnosis.