Table 5.
Diagnostic accuracy of secondary measures.
| Description | Threshold (Optimal) | Sensitivity (95% CI) | Specificity (95% CI) | AUC (95% CI) | |
|---|---|---|---|---|---|
| OCL accuracy (z-score) | A−T− vs A+T− among CU | 0.18 | 0.56 (0.44, 0.69) | 0.58 (0.50, 0.66) | 0.53 (0.44, 0.62) |
| A−T− vs A+T+ among CU | −0.21 | 0.45 (0.27, 0.64) | 0.77 (0.70, 0.83) | 0.60 (0.49, 0.71) | |
| CU stable vs converter | −0.13 | 0.63 (0.55, 0.70) | 0.67 (0.63, 0.72) | 0.68 (0.63, 0.72) | |
| OCL accuracy (Arcsine transformed raw score) | A−T− vs A+T− among CU | 0.66 | 0.48 (0.34, 0.61) | 0.68 (0.61, 0.76) | 0.55 (0.46, 0.64) |
| A−T− vs A+T+ among CU | 0.66 | 0.55 (0.39, 0.70) | 0.68 (0.60, 0.75) | 0.62 (0.51, 0.73) | |
| CU stable vs converter | 0.64 | 0.60 (0.51, 0.68) | 0.70 (0.65, 0.74) | 0.67 (0.62, 0.72) | |
| AVLT delay (raw score)1 | A−T− vs A+T− among CU | 9.50 | 0.83 (0.73, 0.92) | 0.42 (0.34, 0.49) | 0.64 (0.57, 0.72) |
| A−T− vs A+T+ among CU | 4.50 | 0.45 (0.30, 0.64) | 0.88 (0.83, 0.93) | 0.67 (0.56, 0.78) | |
| CU stable vs converter | 7.50 | 0.70 (0.63, 0.78) | 0.61 (0.56, 0.65) | 0.70 (0.65, 0.75) | |
| STMS (raw score)1 | A−T− vs A+T− among CU | 36.5 | 0.67(0.56,0.79) | 0.58(0.50,0.66) | 0.67(0.59,0.74) |
| A−T− vs A+T+ among CU | 35.5 | 0.41(0.25,0.56) | 0.71(0.64,0.78) | 0.57(0.46,0.68) | |
| CU stable vs converter | 34.5 | 0.62(0.55,0.70) | 0.75(0.71,0.79) | 0.74(0.69,0.78) | |
Note. A = amyloid; T = tau; OCL = One Card Learning; AVLT = Auditory Verbal Learning Test 30-Minute Delayed Recall. STMS = Short Test of Mental Status.
1
Performance is considered as part of consensus diagnosis.