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. Author manuscript; available in PMC: 2021 Mar 23.
Published in final edited form as: Nature. 2020 Sep 23;586(7827):145–150. doi: 10.1038/s41586-020-2761-3

Figure 2 |. Antibiotic activity and in vivo efficacy of selected group A streptogramins.

Figure 2 |

a, MIC values for selected analogs against an expanded panel of pathogens. The bars to the right display in vitro translation that occurs in the presence of 10 μM of each analog (relative to DMSO). b, MIC values against eight clinical isolates of S. aureus with Vat resistance genes. The (*) indicates MIC values that were obtained in technical triplicate and biological triplicate. c, A murine thigh model of infection with S. aureus CIP 111304 (n=5 biologically independent animals per group, with the exception of the 2 h infection control where n=4 per group, examined over one experiment). Each animal is individually plotted, the center line is the mean, and the upper and lower whiskers bound the standard deviation from the mean. For detailed statistical analysis, see Extended Data Table 3.