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. 2020 Oct 8;10:16778. doi: 10.1038/s41598-020-73440-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Resistome of K. pneumoniae bla_KPC-2 and bla_KPC-3 cluster isolates. K. pneumoniae bla_KPC-2 and bla_KPC-3 cluster isolates were indicated on the y-axis and AMR genes on the x-axis. All isolates analysed contained the fosA, oqxA and oqxB AMR genes and were not included in this figure. The clustering was based on the presence (squares) and absence of AMR genes. Antibiotic classes are indicated above the AMR genes in different colors. Resistance genes in K. pneumoniae bla_KPC-2 or bla_KPC-3 cluster isolates that were sequenced with TGS were marked with green squares. Genetic relatedness was depicted in an UPGMA tree in which K. pneumoniae bla_KPC-2 isolates were marked with blue branches, and K. pneumoniae bla_KPC-3 were marked magenta. Dutch KpnCluster-019 isolates were marked with an *. A dotted line marks the 85% cut off.