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. 2020 Oct 8;10:16848. doi: 10.1038/s41598-020-74016-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Associations of serum cytokine/chemokine levels with lipid measures, arthritis activity, and diet in 21 week-old K/BxN mice are shown. Serum cytokine/chemokine levels were assessed using Luminex-based 20 plex assays for the 29 21 week-old K/BxN mice from Fig. 1. (A) Cytokine/chemokine profiles are generally greater in the more arthritic males compared to less arthritic females. (B) No significant cytokine/chemokine differences were noted between mice on a chow versus atherogenic diet with the exception of G-CSF, which was higher in the mice fed an atherogenic diet. (C) Correlations of cytokine/chemokine levels with arthritic hindlimb scores and laboratory assays are shown. Of note, IL-4, IL-5, IL-10, TNF-α, IP-10, MIG, MIP-1α, and VEGF were assessed in the Luminex panel but values were too low in majority of specimens to allow reliable analysis. Hindlimb score = mean caliper measurement. HDL-C = HDL cholesterol. TC = total cholesterol. PON1 = paraoxonase activity. Lactonase = lactonase activity Data represent Mean ± SEM. *p < 0.05 for test of Spearman Correlation Coefficient.