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. 2020 Oct 8;10:16848. doi: 10.1038/s41598-020-74016-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Arthritic K/BxN mice were bred from non-arthritic C57B6/Ag7 females and KRN males to evaluate bioactive lipid mediators (BLM) in murine inflammatory arthritis. All mice were maintained on a standard mouse chow diet until sacrifice at 9 weeks (n = 10; 5 M/5F), 14 weeks (n = 12; 6 M/6F), and 21 weeks (n = 7; 2 M/5F) [arthritic K/BxN mice = 29] and 14 weeks KRN (n = 10; 5 M/5F) and C57Bl/6-Ag7 (n = 10; 5 M/6F), [non-arthritic controls = 21]. 16 RA patients with atherosclerotic plaque identified on carotid ultrasound were also compared to 16 matched RA patients without plaque and 16 non-RA healthy controls. Mouse and human RA groups were compared to controls as described in the “Materials and methods”. (A) PON1 activities. (B) Bioactive lipid mediators (BLM). (C) Correlations of BLM with PON1 activities.