Table E1.
Prognostic accuracy of vital signs and clinical scoring systems alone and in combination with top predicting biomarkers for 30-day oxygen requirement in patients with COVID-19
| Model | AUROC (95% CI) |
||
|---|---|---|---|
| Clinical parameter | (+) IL-6 | (+) IL-8 | |
| Heart rate | 0.70 (0.59-0.83) | 0.87 (0.78-0.97)∗ | 0.86 (0.77-0.94)∗ |
| Respiratory rate | 0.72 (0.59-0.84) | 0.85 (0.76-0.95)∗ | 0.85 (0.76-0.94)∗ |
| qSOFA | 0.66 (0.54- 0.78) | 0.84 (0.74-0.94)∗ | 0.85 (0.75-0.94)∗ |
| CRB-65 | 0.67 (0.55-0.78) | 0.83 (0.72-0.93)∗ | 0.83 (0.73-0.92)∗ |
| IL-6 | 0.84 (0.75-0.94) | ||
| IL-8 | 0.82 (0.72-0.92) | ||
Missing values: CRB-65 4, qSOFA 3, Heart rate 1, Respiratory rate 1.
AUROCs were calculated from the predictive probabilities of logistic regression models to 30-d oxygen requirement. Clinical parameter AUROC alone and combined with IL-6 or IL-8 are presented. Differences in AUROCs were assessed using the DeLong method.
∗
P < .05 comparing the clinical parameter AUROC vs the combined clinical parameter with IL-6 or IL-8 AUROC.